Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA.

doi:10.1016/j.humimm.2007.05.005

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Article

Environment-gene interaction in multiple sclerosis: human herpesvirus 6 and MHC2TA.

Human immunology - 1 Aug 2007

Martínez Alfonso, Alvarez-Lafuente Roberto, Mas Ana, Bartolomé Manuel, García-Montojo Marta, de Las Heras Virginia, de la Concha Emilio G, Arroyo Rafael, Urcelay Elena

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory disorder affecting the central nervous system, in which both genetic and environmental factors interact. Among these environmental contributors, herpesvirus has been proposed as an important etiologic factor. CIITA is a transcription factor controlling the expression of MHC class II genes, the main genetic determinants of MS susceptibility. This gene has been described...

Topics

Adolescent
Adult
Child
Female
Genetic Predisposition to Disease
Herpesvirus 6, Human
Humans
Male
Multiple Sclerosis
Nuclear Proteins
Polymorphism, Single Nucleotide
Roseolovirus Infections
Trans-Activators

Source

Open in PubMed

Identifiers

PMID: 17678724
DOI: 10.1016/j.humimm.2007.05.005

Genes

CIITA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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