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Article

Perturbation of retinoic acid (RA)‐mediated limb development suggests a role for diminished RA signaling in the teratogenesis of ethanol

3 Aug 2007

Abstract excerpt

BACKGROUND: A proposed mechanism for ethanol teratogenicity entails ethanol-mediated reductions in retinoic acid (RA). This premise was investigated utilizing a mouse model, with limb reduction defects as the teratogenic end point. METHODS: Ethanol, Disulfiram, or BMS-189453 was administered to C57BL/6J mice on the 9(th) day of pregnancy. Forelimb morphology was assessed on gestation day 18 using Alcian blue and...

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PMID: 17676605
DOI: 10.1002/bdra.20385

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