Article
Activation of BTAK expression in primary ovarian surface epithelial cells of prophylactic ovaries.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2007
Zhang Zhihong, Singh Meenakshi, Davidson Susan, Rosen Daniel G, Yang Gong, Liu Jinsong
Abstract excerpt
The ovarian epithelial cells carrying heterozygous BRCA1 or BRCA2 mutation (we called BRCA1/2 mutation) are known to predispose to the development of ovarian cancer; however, the molecular basis of such predisposition is largely unknown. We hypothesize that BTAK may be a potential target for heterozygous BRCA1/2 mutation. We sought to determine the relationship between the status of BRCA1/2 heterozygous mutation...
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