Article
FGFR3 and PIK3CA mutations are involved in the molecular pathogenesis of solar lentigo.
The British journal of dermatology - 1 Mar 2009
Hafner C, Stoehr R, van Oers J M M, Zwarthoff E C, Hofstaedter F, Landthaler M, Hartmann A, Vogt T
Abstract excerpt
BACKGROUND: Solar lentigines (SL) are frequent benign skin lesions appearing on sun-exposed areas especially in elderly people and therefore represent a hallmark of (photo)aged skin. It has been proposed that SL may subsequently evolve into adenoid seborrhoeic keratosis (SK). However, little is known about the genetic basis of SL. In human SK, FGFR3 and PIK3CA mutations have recently been identified. OBJECTIVES:...
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