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Article

[Genetic basis of seborrheic keratosis and epidermal nevi].

Der Pathologe - 1 Sept 2014

Hafner C, Hafner H, Groesser L

Abstract excerpt

Seborrheic keratosis (SK) and epidermal nevi (EN) represent benign skin tumors and congenital lesions, respectively. Oncogenic mutations are fundamentally involved in their pathogenesis and SK is characterized by a broad spectrum of somatic mutations in the FGFR3, PIK3CA, RAS, AKT1 and EGFR genes. In contrast to malignant tumors, SK is genetically stable without alterations of tumor suppressor genes. The ENs are...

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Source

Identifiers

PMID: 25187080
DOI: 10.1007/s00292-014-1928-9

Genes

FGFR3
AKT1
EGFR
HRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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