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Article

Transcriptomic Classification of Pituitary Neuroendocrine Tumors Causing Acromegaly

30 Nov 2022

Abstract excerpt

Acromegaly results from growth hormone hypersecretion, predominantly caused by a somatotroph pituitary neuroendocrine tumor (PitNET). Acromegaly-causing tumors are histologically diverse. Our aim was to determine transcriptomic profiles of various somatotroph PitNETs and to evaluate clinical implication of differential gene expression. A total of 48 tumors were subjected to RNA sequencing, while expression of...

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PMID: 36497102
DOI: 10.3390/cells11233846

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