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Article

Clinical characteristics associated with somatic GNAS mutations in acromegaly: a systematic review and institutional experience.

Frontiers in endocrinology - 1 Jan 2026

Dillon Brendan R, Ruddy Margaret, McQuade Emily C, Shah Shruti N, Twi-Yeboah Alberta, Levinson Benjamin A, Agrawal Nidhi

Abstract excerpt

Introduction: Acromegaly is a rare, insidious disease associated with significant morbidity and mortality usually caused by a growth hormone (GH)-secreting pituitary tumor. Somatic mutations in GNAS are common in these tumors, yet their diagnostic, prognostic, and therapeutic implications are less clear. Methods: We conducted a structured review of the literature and meta-analysis to investigate the association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

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Source

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Identifiers

PMID: 41648725
DOI: 10.3389/fendo.2026.1736208
PMCID: PMC12867796

Genes

GNAS
SRL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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