Article
Talin influences the dynamics of the myosin VII-membrane interaction.
Molecular biology of the cell - 1 Oct 2007
Galdeen Shawn A, Stephens Stephen, Thomas David D, Titus Margaret A
Abstract excerpt
Myosin VII (M7) and talin are ancient and ubiquitous actin-binding proteins with conserved roles in adhesion. Talin serves to link membrane receptors to the underlying actin cytoskeleton and forms a complex with M7 in Dictyostelium. The levels of talinA are tightly linked to M7 levels in Dictyostelium. Cells lacking M7 exhibit an 80% decrease in steady-state levels of talinA, whereas increased levels of M7 result...
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