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Article

PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney.

Human pathology - 1 Sept 2007

Vranić Semir, Bilalović Nurija, Lee Lisa M J, Kruslin Bozo, Lilleberg Stan L, Gatalica Zoran

Abstract excerpt

Adenoid cystic carcinoma (ACC) of the breast rarely metastasizes and has been associated with excellent prognosis. We describe a patient with renal metastasis of primary breast ACC 5 years after the mastectomy. A detailed molecular genetic analysis of the primary and metastatic tumors demonstrated somatic mutations in 2 well-known cancer genes associated with regulation of PI3K/AKT signaling pathway: (1) PIK3CA,...

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Topics

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Share to Chromatography, High Pressure Liquid
Share to Class I Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Complementary

Share to Immunohistochemistry

Share to Kidney Neoplasms

Share to Phosphatidylinositol 3-Kinases

Share to PTEN Phosphohydrolase

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 17669465
DOI: 10.1016/j.humpath.2007.03.021

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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