Article
SOCS3 and IRS-1 gene expression differs between genotype 1 and genotype 2 hepatitis C virus-infected HepG2 cells.
Clinical chemistry and laboratory medicine - 1 Jan 2009
Persico Marcello, Russo Roberta, Persico Eliana, Svelto Monica, Spano Daniela, Andolfo Immacolata, La Mura Vincenzo, Capasso Mario, Tiribelli Claudio, Torella Roberto, Iolascon Achille
Abstract excerpt
BACKGROUND: The poor response to antiviral treatment of hepatitis C virus (HCV)-infected patients with genotype 1b has been associated with a higher prevalence of metabolic syndrome. However, the molecular link between these clinical entities is not clear. The goal of this study was to clarify the role of genotype 1b and 2 in the genetic expression of suppressor of cytokine signaling 3 (SOCS3) and insulin...
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