Article
Association between FAS polymorphism and prostate cancer development.
Prostate cancer and prostatic diseases - 1 Jan 2008
Lima L, Morais A, Lobo F, Calais-da-Silva F M, Calais-da-Silva F E, Medeiros R
Abstract excerpt
The role of FAS polymorphisms in prostate cancer has not been studied. Using the PCR-based restriction fragment-length polymorphism methodology, we evaluated FAS gene locus -670 genotypes in DNA from 904 men: 657 prostate cancer patients and 247 healthy controls. We found that carriers of AG or GG genotypes have a statistically significant protection (odds ratio (OR)=0.30; confidence interval (CI): 0.20-0.44 and...
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