Article
CYP2D6 and CYP2C19 genotype-based dose recommendations for antidepressants: a first step towards subpopulation-specific dosages.
Acta psychiatrica Scandinavica - 1 Sept 2001
Kirchheiner J, Brøsen K, Dahl M L, Gram L F, Kasper S, Roots I, Sjöqvist F, Spina E, Brockmöller J
Abstract excerpt
OBJECTIVE: This review aimed to provide distinct dose recommendations for antidepressants based on the genotypes of cytochrome P450 enzymes CYP2D6 and CYP2C19. This approach may be a useful complementation to clinical monitoring and therapeutic drug monitoring. METHOD: Our literature search covered 32 antidepressants marketed in Europe, Canada, and the United States. We evaluated studies which had compared...
Topics
- Antidepressive Agents
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 CYP2D6
- Cytochrome P-450 Enzyme System
- Depressive Disorder
- Dose-Response Relationship, Drug
- Drug Monitoring
- Female
- Genotype
- Humans
- Male
- Mixed Function Oxygenases