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Fluoroquinolone‐ResistantStreptococcus pneumoniaeAssociated with Levofloxacin Therapy

15 Sept 2001

Abstract excerpt

Fluoroquinolone-resistant cultures of Streptococcus pneumoniae were isolated from 2 patients who were treated for pneumonia with levofloxacin. Nucleotide sequence analysis of bacterial DNA showed that the isolates contained mutations in both parC (DNA topoisomerase IV) and gyrA (DNA gyrase), which were shown previously to confer fluoroquinolone resistance. With the resistant isolates, the MICs for ciprofloxacin,...

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Identifiers

PMID: 11517444
DOI: 10.1086/323086

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