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Article

Pharmacodynamic modeling of the evolution of levofloxacin resistance in Staphylococcus aureus.

Antimicrobial agents and chemotherapy - 1 Jun 2005

Campion Jeffrey J, Chung Philip, McNamara Patrick J, Titlow William B, Evans Martin E

Abstract excerpt

Previously, we demonstrated the importance of low-level-resistant variants to the evolution of resistance in Staphylococcus aureus exposed to ciprofloxacin in an in vitro system and developed a pharmacodynamic model which predicted the emergence of resistance. Here, we examine and model the evolution of resistance to levofloxacin in S. aureus exposed to simulated levofloxacin pharmacokinetic profiles. Enrichment...

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Identifiers

PMID: 15917512
DOI: 10.1128/AAC.49.6.2189-2199.2005
PMCID: PMC1140504

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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