Article
Pharmacodynamics of moxifloxacin and levofloxacin at simulated epithelial lining fluid drug concentrations against Streptococcus pneumoniae.
Antimicrobial agents and chemotherapy - 1 Apr 2004
Florea Naomi R, Tessier Pamela R, Zhang Cuilian, Nightingale Charles H, Nicolau David P
Abstract excerpt
Recent clinical failures associated with levofloxacin treatment for Streptococcus pneumoniae infections and growing evidence of frequent mutations in the isolate population have led to increased concerns regarding fluoroquinolone resistance. Our objective was to characterize the efficacies of levofloxacin and moxifloxacin against various genotypes of S. pneumoniae after simulated bronchopulmonary exposures. An in...
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