Article
Essential roles of myosin phosphatase in the maintenance of epithelial cell integrity of Drosophila imaginal disc cells.
Developmental biology - 1 Sept 2007
Mitonaka Tomoaki, Muramatsu Yoshiyuki, Sugiyama Shin, Mizuno Tomoaki, Nishida Yasuyoshi
Abstract excerpt
Reorganization of the actin cytoskeleton and contraction of actomyosin play pivotal roles in controlling cell shape changes and motility in epithelial morphogenesis. Dephosphorylation of the myosin regulatory light chain (MRLC) by myosin phosphatase is one of the key events involved. Allelic combinations producing intermediate strength mutants of the Drosophila myosin-binding subunit (DMBS) of myosin phosphatase...
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