Article
Dystroglycan is required for polarizing the epithelial cells and the oocyte in Drosophila.
Development (Cambridge, England) - 1 Jan 2003
Deng Wu-Min, Schneider Martina, Frock Richard, Castillejo-Lopez Casimiro, Gaman Emily Anne, Baumgartner Stefan, Ruohola-Baker Hannele
Abstract excerpt
The transmembrane protein Dystroglycan is a central element of the dystrophin-associated glycoprotein complex, which is involved in the pathogenesis of many forms of muscular dystrophy. Dystroglycan is a receptor for multiple extracellular matrix (ECM) molecules such as Laminin, agrin and perlecan, and plays a role in linking the ECM to the actin cytoskeleton; however, how these interactions are regulated and...
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