Article
The spectrum of hearing loss due to mitochondrial DNA defects.
Brain : a journal of neurology - 1 Jan 2000
Chinnery P F, Elliott C, Green G R, Rees A, Coulthard A, Turnbull D M, Griffiths T D
Abstract excerpt
Heteroplasmic mitochondrial DNA (mtDNA) defects are an important cause of neurological disease. Although hearing impairment is common in patients with mtDNA defects, the spectrum and pathophysiology of the hearing loss is not well characterized. We therefore studied the relationship between cochlear and brainstem auditory function in 23 patients harbouring a range of different mtDNA mutations. Based upon the pure...
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