Article
Vacuolar protein sorting pathway contributes to the release of Marburg virus.
Journal of virology - 1 Mar 2009
Kolesnikova Larissa, Strecker Thomas, Morita Eiji, Zielecki Florian, Mittler Eva, Crump Colin, Becker Stephan
Abstract excerpt
VP40, the major matrix protein of Marburg virus, is the main driving force for viral budding. Additionally, cellular factors are likely to play an important role in the release of progeny virus. In the present study, we characterized the influence of the vacuolar protein sorting (VPS) pathway on the release of virus-like particles (VLPs), which are induced by Marburg virus VP40. In the supernatants of HEK 293...
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