Article
beta-Glucan of Candida albicans cell wall causes the subversion of human monocyte differentiation into dendritic cells.
Journal of leukocyte biology - 1 Nov 2007
Nisini Roberto, Torosantucci Antonella, Romagnoli Giulia, Chiani Paola, Donati Simona, Gagliardi Maria Cristina, Teloni Raffaela, Sargentini Valeria, Mariotti Sabrina, Iorio Egidio, Cassone Antonio
Abstract excerpt
The functional consequences of treating human monocytes with purified and chemically characterized Candida albicans beta-glucan -- a major microbial pathogen associated molecular pattern -- on their differentiation into dendritic cells (DC) were investigated. We show here that beta-glucan-treated monocytes differentiated into mature DC (Glu-MoDC) with altered phenotype and functional behavior, similarly to DC...
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