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DNA topoisomerases I and II in human mature sperm cells: characterization and unique properties

26 Jul 2007

Abstract excerpt

BACKGROUND: The condensed state of the human sperm's chromatin is essential for the compact structure of the spermatozoon head, which is important for the fertilization process. The enzymes DNA topoisomerases (topo I and topo II) are responsible for the topological structure of the chromatin in somatic cells. The activities and the characterization of topoisomerases in mature human sperm cells have not been...

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PMID: 17656417
DOI: 10.1093/humrep/dem170

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