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CHROMATIN REMODELING IN SPERMATIDS: A SENSITIVE STEP FOR THE GENETIC INTEGRITY OF THE MALE GAMETE

1 Jan 2005

Abstract excerpt

Several causes of male infertility remain idiopathic. Recently, the condensed state of the sperm head has been demonstrated as a discriminating parameter for the assessment of male infertility. Altered DNA condensation is associated with an increase in DNA strand breakage so the genetic integrity of the male gamete is threatened. The origin of the DNA strand breaks in unknown. However, transient DNA strand breaks...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 15804867
DOI: 10.1080/014850190518134

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