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Article

Spermiogenesis and DNA Repair: A Possible Etiology of Human Infertility and Genetic Disorders

1 Jan 2008

Abstract excerpt

This paper reviews the possible origin of sperm DNA fragmentation and focuses on the nuclear events associated with spermiogenesis as a potential source of genetic instability and reduced fertilizing potential of the mature male gamete. Recent findings suggest a programmed DNA fragmentation and DNA damage response during the chromatin remodeling steps in spermatids. We also discuss the spermatid DNA repair...

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Identifiers

PMID: 18543861
DOI: 10.1080/19396360701876823

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