Article
Polymorphisms involved in the folate metabolizing pathway and risk of multiple myeloma.
American journal of hematology - 1 Sept 2007
Kim Hee Nam, Kim Yeo-Kyeoung, Lee Il-Kwon, Lee Je-Jung, Yang Deok-Hwan, Park Kyeong-Soo, Choi Jin-Su, Park Moo Rim, Jo Deog Yeon, Kim Hyeoung-Joon
Abstract excerpt
Folate and methionine metabolism plays an essential role in both DNA synthesis and methylation. Polymorphisms in the genes of the folate-dependent enzymes have been shown to affect disease susceptibility. We conducted a Korean population-based case-control study to evaluate whether genetic variation in folate metabolism may have a role in the risk of multiple myeloma (MM). The study subjects were 173 patients...
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