Article
5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.
Journal of medicinal chemistry - 23 Aug 2007
Madsen Christian, Jensen Anders A, Liljefors Tommy, Kristiansen Uffe, Nielsen Birgitte, Hansen Camilla P, Larsen Mogens, Ebert Bjarke, Bang-Andersen Benny, Krogsgaard-Larsen Povl, Frølund Bente
Abstract excerpt
A series of ring-substituted analogues of imidazole-4-acetic acid (IAA, 4), a partial agonist at both GABAA and GABAC receptors (GABA = gamma-aminobutyric acid), have been synthesized. The synthesized compounds 8a-l have been evaluated as ligands for the alpha1beta2gamma2S GABAA receptors and the rho1 GABAC receptors using the FLIPR membrane potential (FMP) assay and by electrophysiology techniques. None of the...
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