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Article

Mutations of the 2' proline in the M2 domain of the human GABAC rho1 subunit alter agonist responses.

Neuropharmacology - 1 May 2004

Carland Jane E, Moore Allison M, Hanrahan Jane R, Mewett Kenneth N, Duke Rujee K, Johnston Graham A R, Chebib Mary

Abstract excerpt

Mutations of the proline residue at the 2' position (P2') within the second transmembrane (M2) domain of the gamma-aminobutyric acid(C) (GABA(C)) rho1 subunit are known to produce receptors with altered pharmacology. In the present study, P2' was mutated to alanine (rho1P2'A), phenylalanine (rho1...

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Identifiers

PMID: 15033337
DOI: 10.1016/j.neuropharm.2003.11.027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15033337-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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