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A Retrospective Analysis of Toxicogenomics in the Safety Assessment of Drug Candidates

26 Jul 2007

Abstract excerpt

Toxicogenomics is considered a valuable tool for reducing pharmaceutical candidate attrition by facilitating earlier identification, prediction and understanding of toxicities. A retrospective evaluation of 3 years of routine transcriptional profiling in non-clinical safety studies was undertaken to assess the utility of toxicogenomics in drug safety assessment. Based on the analysis of studies with 33 compounds,...

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PMID: 17654404
DOI: 10.1080/01926230701419063

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