Article
Use of traditional end points and gene dysregulation to understand mechanisms of toxicity: toxicogenomics in mechanistic toxicology.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2008
Buck Wayne R, Waring Jeffrey F, Blomme Eric A
Abstract excerpt
Microarray technologies can be used to generate massive amounts of gene expression information as an initial step to decipher the molecular mechanisms of toxicologic changes. Identifying genes whose expression is associated with specific toxic end points is an initial step in predicting, characte...
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