Article
Extent of linkage disequilibrium in a Sardinian sub-isolate: sampling and methodological considerations.
Human molecular genetics - 1 Jan 2004
Tenesa A, Wright A F, Knott S A, Carothers A D, Hayward C, Angius A, Persico I, Maestrale G, Hastie N D, Pirastu M, Visscher P M
Abstract excerpt
The extent of linkage disequilibrium (LD) is an important factor when designing experiments for mapping disease or trait loci using LD mapping methods. It depends on the population history and hence is a characteristic of each population. Here, we have assessed the extent of LD in a sub-isolate of the general Sardinian population (775 members of one village) using 22 polymorphic markers on chromosome 19. We found...
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