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Article

Peptides from conserved regions of paramyxovirus fusion (F) proteins are potent inhibitors of viral fusion.

5 Mar 1996

Abstract excerpt

The synthetic peptides DP-107 and DP-178 (T-20), derived from separate domains within the human immunodeficiency virus type 1 (HIV-1) transmembrane (TM) protein, gp4l, are stable and potent inhibitors of HIV-1 infection and fusion. Using a computer searching strategy (computerized antiviral searching technology, C.A.S.T.) based on the predicted secondary structure of DP-107 and DP-178 (T-20), we have identified...

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PMID: 8700906
DOI: 10.1073/pnas.93.5.2186

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