Article
Is altered adrenal steroid biosynthesis a key intermediate phenotype in hypertension?
Hypertension (Dallas, Tex. : 1979) - 1 May 2003
Connell John M C, Fraser Robert, MacKenzie Scott, Davies Eleanor
Abstract excerpt
Approximately 10% of patients with hypertension have a high ratio of aldosterone to renin, but the reason for this and the relationships among low-renin essential hypertension, elevation of the ratio, and true primary aldosteronism are unclear. We have previously reported that a polymorphism of the gene (C-to-T conversion at position -344) encoding aldosterone synthase is associated with hypertension,...
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