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A novel esterase regulates Klebsiella pneumoniae hypermucoviscosity and virulence

31 Oct 2024

Abstract excerpt

Klebsiella pneumoniae, an emerging multidrug-resistant pathogen, exhibits hypermucoviscosity (HMV) as a critical virulence trait mediated by its capsular polysaccharide (CPS). Recent discoveries have determined acetylation as a significant modification for CPS, although its impact on HMV and virulence was previously unknown. This study elucidates the roles of two enzymes: Klebsiella pneumoniae Acetylated CPS...

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PMID: 39480904
DOI: 10.1371/journal.ppat.1012675

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