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Article

Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1.

American journal of respiratory cell and molecular biology - 1 Dec 2007

Koth Laura L, Alex Byron, Hawgood Samuel, Nead Michael A, Sheppard Dean, Erle David J, Morris David G

Abstract excerpt

Surfactant lines the alveolar surface and prevents alveolar collapse. Derangements of surfactant cause respiratory failure and interstitial lung diseases. The collectins, surfactant proteins A and D, are also important in innate host defense. However, surfactant regulation in the postnatal lung is poorly understood. We found that the epithelial integrin, alphavbeta6, regulates surfactant homeostasis in vivo by...

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Share to Bronchoalveolar Lavage Fluid
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 17641300
DOI: 10.1165/rcmb.2006-0428OC
PMCID: PMC2219547

Genes

SMAD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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