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Article

A mathematical model for evaluating the reaction of paraoxon with human serum cholinesterase and with polymorphic forms of paraoxonase.

Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000

Eckerson H W, La Du B N

Abstract excerpt

The inhibition of cholinesterase of human serum by paraoxon can be predicted by a mathematical model which considers two competing reactions for paraoxon: one, the direct interaction with cholinesterase, and the other, enzymatic hydrolysis by paraoxonase. On the basis of the residual cholinesterase activity at various times during the incubation with paraoxon, it is possible to determine the rate constants for...

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PMID: 6141913

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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