Article
A mathematical model for evaluating the reaction of paraoxon with human serum cholinesterase and with polymorphic forms of paraoxonase.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Eckerson H W, La Du B N
Abstract excerpt
The inhibition of cholinesterase of human serum by paraoxon can be predicted by a mathematical model which considers two competing reactions for paraoxon: one, the direct interaction with cholinesterase, and the other, enzymatic hydrolysis by paraoxonase. On the basis of the residual cholinestera...
Topics
- Aryldialkylphosphatase
- Cholinesterases
- Humans
- Hydrolysis
- Kinetics
- Mathematics
- Models, Biological
- Paraoxon
- Phenotype
- Phosphoric Monoester Hydrolases