Article
Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes.
Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 1999
Zhou M, Engel A G, Auerbach A
Abstract excerpt
We have found that mutant acetylcholine receptor channels (AChRs) that cause slow-channel congenital myasthenic syndromes are activated by serum and that the high frequency of openings in serum is reduced by treatment with choline oxidase. Thus, slow-channel congenital myasthenic syndrome AChRs at the neuromuscular junction are likely to be activated both by steady exposure to serum choline and by transient...
Topics
- Animals
- Cell Line
- Choline
- Humans
- Kidney
- Membrane Potentials
- Mice
- Mutation
- Myasthenia Gravis
- Patch-Clamp Techniques
- Point Mutation
- Receptors, Cholinergic
- Syndrome
- Transfection