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Article

Serum choline activates mutant acetylcholine receptors that cause slow channel congenital myasthenic syndromes.

Proceedings of the National Academy of Sciences of the United States of America - 31 Aug 1999

Zhou M, Engel A G, Auerbach A

Abstract excerpt

We have found that mutant acetylcholine receptor channels (AChRs) that cause slow-channel congenital myasthenic syndromes are activated by serum and that the high frequency of openings in serum is reduced by treatment with choline oxidase. Thus, slow-channel congenital myasthenic syndrome AChRs at the neuromuscular junction are likely to be activated both by steady exposure to serum choline and by transient...

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Identifiers

PMID: 10468632
DOI: 10.1073/pnas.96.18.10466
PMCID: PMC17912

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Source receipt: pubmed, retrieved 7 Sept 2026.

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