Article
Variants in the CRP gene as a measure of lifelong differences in average C-reactive protein levels: the Cardiovascular Risk in Young Finns Study, 1980-2001.
American journal of epidemiology - 1 Oct 2007
Kivimäki Mika, Lawlor Debbie A, Smith George Davey, Eklund Carita, Hurme Mikko, Lehtimäki Terho, Viikari Jorma S A, Raitakari Olli T
Abstract excerpt
Genetic association studies have used variants in the C-reactive protein (CRP) gene to estimate causal effects of lifelong circulating CRP levels on disease endpoints. However, the extent to which the genetic variants are actually associated with lifelong circulating CRP levels has not been demonstrated empirically. In a population-based prospective cohort study (1980-2001) of 1,609 young Finns (768 men and 841...
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