Article
CRP gene variation and risk of community-acquired pneumonia.
Respirology (Carlton, Vic.) - 1 Jan 2010
Mukamal Kenneth J, Pai Jennifer K, O'Meara Ellen S, Tracy Russell P, Psaty Bruce M, Kuller Lewis H, Newman Anne B, Yende Sachin, Curhan Gary C, Siscovick David S, Rimm Eric B
Abstract excerpt
BACKGROUND AND OBJECTIVE: CRP has several potentially antibacterial effects, and variation in the CRP gene is known to influence CRP levels. Whether this variation influences risk of infection, and hence whether CRP has anti-infective activity in humans, is uncertain. METHODS: We evaluated a series of haplotype-tagging single nucleotide polymorphisms among 5374 individuals in the Cardiovascular Health Study, a...
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