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Fibroblast‐derived exosomal microRNA regulates NKX3‐1 expression in androgen‐sensitive, androgen receptor‐dependent prostate cancer cells

19 Jun 2023

Abstract excerpt

Androgen deprivation therapy (ADT) targeting androgen production and androgen receptor (AR) signaling is the primary antihormonal therapy in the treatment of advanced prostate cancer (PCa). However, no clinically established molecular biomarkers have been identified to predict the effectiveness of ADT before starting ADT. The tumor microenvironment of PCa contains fibroblasts that regulate PCa progression by...

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PMID: 37334663
DOI: 10.1002/jcb.30435

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