Article
Identifying haplotype block structure using an ancestor-derived model.
Journal of human genetics - 1 Jan 2007
Fujisawa Hironori, Isomura Minoru, Eguchi Shinto, Ushijima Masaru, Miyata Satoshi, Miki Yoshio, Matsuura Masaaki
Abstract excerpt
Recently, haplotype-based association studies have become popular for detecting disease-related or drug-response-associated genes. In these studies, it has been gradually recognized that a haplotype block structure is important. A rational and automatic method for identifying the haplotype block structure from SNP data has been desired. We have developed a new method using an ancestor-derived model and the...
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