Article
Genetic polymorphism of cytochrome P450s and P-glycoprotein in the Finnish population.
Fundamental & clinical pharmacology - 1 Aug 2007
Hilli Johanna, Rane Anders, Lundgren Stefan, Bertilsson Leif, Laine Kari
Abstract excerpt
The objective of this study was to investigate the genetic polymorphism of selected cytochrome P450 (CYP) enzymes and ABCB1 (encoding P-glycoprotein) of central importance with regard to the disposition of clinically used drugs in the Finnish population and to compare the results to pre-existing data from Caucasian populations. A random sample of 449 Finns was studied. Single nucleotide polymorphisms (SNPs) were...
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