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Article

Structural and dynamic effects of alpha-helix deletion in Sso7d: implications for protein thermal stability.

Proteins - 1 Dec 2004

Merlino Antonello, Graziano Giuseppe, Mazzarella Lelio

Abstract excerpt

Sso7d is a 62-residue protein from the hyperthemophilic archaeon Sulfolobus solfataricus with a denaturation temperature close to 100 degrees C around neutral pH. An engineered form of Sso7d truncated at leucine 54 (L54Delta) is significantly less stable, with a denaturation temperature of 53 degrees C. Molecular dynamics (MD) studies of Sso7d and its truncated form at two different temperatures have been...

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Identifiers

PMID: 15317021
DOI: 10.1002/prot.20270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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