Article
Platelet glycoprotein Ibalpha polymorphisms and function evaluated by the platelet function analyzer PFA-100 in patients with lupus anticoagulant: the association with thromboembolic disease.
Annals of hematology - 1 Oct 2007
Jilma-Stohlawetz Petra, Jilma Bernd, Mannhalter Christine, Bencur Peter, Pabinger Ingrid, Vormittag Rainer, Dunkler Daniela, Panzer Simon
Abstract excerpt
Lupus anticoagulants (LA) are a surrogate marker for the risk of thromboembolic disease (TE). However, not all individuals with LA acquire TE, and it is desirable to distinguish those at risk for TE from those without. Platelets polymorphisms may contribute to the risk of TE, mainly those of glycoprotein (GP)Ibalpha: these are the variable number of tandem repeats (VNTR) and a dimorphism in the Kozak region,...
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