Article
Glycoprotein Ib polymorphisms influence platelet plug formation under high shear rates.
British journal of haematology - 1 Feb 2003
Jilma-Stohlawetz Petra, Homoncik Monika, Jilma Bernd, Knechtelsdorfer Maarten, Unger Petra, Mannhalter Christine, Santoso Sentot, Panzer Simon
Abstract excerpt
Platelet polymorphisms (Kozak, VNTR and HPA-2) within glycoprotein (GP)Ib alpha may be associated with an increased risk of arterial thrombosis. However, the functional role of these polymorphisms has not been clarified. Their influence on platelet plug formation under high shear rates was, therefore, examined in 233 healthy individuals. Collagen-adrenaline-induced closure time was shorter in carriers of the C/D...
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