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Article

CXCL12 Activates a Robust Transcriptional Response in Human Prostate Epithelial Cells

14 Jul 2007

Abstract excerpt

CXCL12 is a CXC-type chemokine that plays important roles in hematopoiesis, development, and organization of the immune system and supports the survival or growth of a variety of normal or malignant cell types. Our laboratory recently showed that CXCL12 is secreted by aging stromal fibroblast cells and is a major paracrine factor that specifically stimulates the proliferation of prostate epithelial cells. The...

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PMID: 17631494
DOI: 10.1074/jbc.m700440200

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