Aging attenuates dynactin–dynein interaction: Down‐regulation of dynein causes accumulation of endogenous tau and amyloid precursor protein in human neuroblastoma cells

Abstract excerpt

Impaired axonal transport may promote pathogenesis in neurodegenerative disorders, such as Alzheimer's disease (AD). We previously showed that tau, amyloid precursor protein (APP), and intracellular amyloid beta-protein (Abeta) accumulate in the nerve-ending fraction of aged monkey brains, perhaps because of impaired axonal transport. In the present study, we assessed age-related changes of axonal transport motor...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Advanced Neuroimaging Techniques and Applications
• Share to Alzheimer's disease research and treatments