Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr.

Journal of virology - 1 Apr 2006

Ardon Orly, Zimmerman Erik S, Andersen Joshua L, DeHart Jason L, Blackett Jana, Planelles Vicente

Abstract excerpt

Cyclophilin A (CypA) is a member of a family of cellular proteins that share a peptidyl prolyl cis-trans isomerase (PPIase) activity. CypA was previously reported to be required for the biochemical stability and function (specifically, induction of G2 arrest) of the human immunodeficiency virus type 1 (HIV-1) protein R (Vpr). In the present study, we examine the role of the Vpr-CypA interaction on Vpr-induced G2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to Cyclophilin A

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G2 Phase

Share to Gene Products, vpr

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 16571786
DOI: 10.1128/JVI.80.8.3694-3700.2006
PMCID: PMC1440437

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of G2 arrest and binding to cyclophilin A are independent phenotypes of human immunodeficiency virus type 1 Vpr.PMID 16571786Read ↗

DDB1 and Cul4A are required for human immunodeficiency virus type 1 Vpr-induced G2 arrest.Semantic proximity Read ↗

The host-pathogen interaction of human cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains.Semantic proximity Read ↗

trans-Complementation rescue of cyclophilin A-deficient viruses reveals that the requirement for cyclophilin A in human immunodeficiency virus type 1 replication is independent of its isomerase activity.Semantic proximity Read ↗

Cyclophilin interactions with incoming human immunodeficiency virus type 1 capsids with opposing effects on infectivity in human cells.Semantic proximity Read ↗

Molecular insight into how HIV-1 Vpr protein impairs cell growth through two genetically distinct pathways.Semantic proximity Read ↗

Cyclosporine A-resistant human immunodeficiency virus type 1 mutants demonstrate that Gag encodes the functional target of cyclophilin A.Semantic proximity Read ↗

Human immunodeficiency virus type 1 Vpr-mediated G(2) cell cycle arrest: Vpr interferes with cell cycle signaling cascades by interacting with the B subunit of serine/threonine protein phosphatase 2A.Semantic proximity Read ↗

Insights into the Roles of Cyclophilin A During Influenza Virus InfectionSemantic proximity Read ↗

Assembly with the Cul4A-DDB1DCAF1 ubiquitin ligase protects HIV-1 Vpr from proteasomal degradation.Semantic proximity Read ↗

A mutation in alpha helix 3 of CA renders human immunodeficiency virus type 1 cyclosporin A resistant and dependent: rescue by a second-site substitution in a distal region of CA.Semantic proximity Read ↗

Active-site residues of cyclophilin A are crucial for its incorporation into human immunodeficiency virus type 1 virions.Semantic proximity Read ↗

Cyclosporine Inhibits Flavivirus Replication through Blocking the Interaction between Host Cyclophilins and Viral NS5 ProteinSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.