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Article

Accelerated geroncogenesis in hereditary breast-ovarian cancer syndrome.

Oncotarget - 15 Mar 2016

Menendez Javier A, Folguera-Blasco Núria, Cuyàs Elisabet, Fernández-Arroyo Salvador, Joven Jorge, Alarcón Tomás

Abstract excerpt

The geroncogenesis hypothesis postulates that the decline in metabolic cellular health that occurs naturally with aging drives a "field effect" predisposing normal tissues for cancer development. We propose that mutations in the cancer susceptibility genes BRCA1/2 might trigger "accelerated geroncogenesis" in breast and ovarian epithelia. By speeding up the rate at which the metabolic threshold becomes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26943589
DOI: 10.18632/oncotarget.7867
PMCID: PMC4914261

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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