Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD.

doi:10.1016/j.ejphar.2012.08.015

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Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD.

European journal of pharmacology - 5 Dec 2012

Budulac Simona E, Postma Dirkje S, Hiemstra Pieter S, Lapperre Thérèse S, Kunz Lisette I Z, Vonk Judith M, Marike Boezen H, Timens Wim

Abstract excerpt

Multidrug resistance-associated protein-1 (MRP1) reduces the oxidative stress generated by smoking, a risk factor for Chronic Obstructive Pulmonary Disease (COPD). We previously showed that MRP1 variants are associated with the level and decline of annual forced expiratory volume in one second (FEV(1)) in the general population. Moreover, we showed that MRP1 variants are also associated with FEV(1) level and...

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Multidrug resistance-associated protein 1 and lung function decline with or without long-term corticosteroids treatment in COPD.

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