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Article

Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants.

Cancer research - 1 Jul 2007

Bolli Niccolò, Nicoletti Ildo, De Marco M Felicetta, Bigerna Barbara, Pucciarini Alessandra, Mannucci Roberta, Martelli Maria Paola, Liso Arcangelo, Mecucci Cristina, Fabbiano Francesco, Martelli Massimo F, Henderson Beric R, Falini Brunangelo

Abstract excerpt

Creation of a nuclear export signal (NES) motif and loss of tryptophans (W) 288 and 290 (or 290 only) at the COOH terminus of nucleophosmin (NPM) are both crucial for NPM aberrant cytoplasmic accumulation in acute myelogenous leukemia (AML) carrying NPM1 mutations. Hereby, we clarify how these CO...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17616680
DOI: 10.1158/0008-5472.CAN-07-0273

Genes

NES
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17616680-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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