Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

Blood - 1 Jun 2006

Falini Brunangelo, Bolli Niccolò, Shan Jing, Martelli Maria Paola, Liso Arcangelo, Pucciarini Alessandra, Bigerna Barbara, Pasqualucci Laura, Mannucci Roberta, Rosati Roberto, Gorello Paolo, Diverio Daniela, Roti Giovanni, Tiacci Enrico, Cazzaniga Giovanni, Biondi Andrea, Schnittger Suzanne, Haferlach Torsten, Hiddemann Wolfgang, Martelli Massimo F, Gu Wei, Mecucci Cristina, Nicoletti Ildo

Abstract excerpt

We recently identified aberrant cytoplasmic expression of nucleophosmin (NPM) as the immunohistochemical marker of a large subgroup of acute myeloid leukemia (AML) (about one-third of adult AML) that is characterized by normal karyotype and mutations occurring at the exon-12 of the NPM gene. In t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to Amino Acid Motifs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Nucleolus

Share to Cytoplasm

Share to Leukemia

Share to Nuclear Export Signals

Share to Nucleophosmin

Share to Tryptophan

Source

Identifiers

PMID: 16455950
DOI: 10.1182/blood-2005-11-4745

Genes

NES

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16455950-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.PMID 16455950Read ↗

Cytoplasmic localization of NPM in myeloid leukemias is dictated by gain-of-function mutations that create a functional nuclear export signal.Semantic proximity Read ↗

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia.Semantic proximity Read ↗

Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features.Semantic proximity Read ↗

A Curious Novel Combination of Nucleophosmin (NPM1) Gene Mutations Leading to Aberrant Cytoplasmic Dislocation of NPM1 in Acute Myeloid Leukemia (AML).Semantic proximity Read ↗

Born to be exported: COOH-terminal nuclear export signals of different strength ensure cytoplasmic accumulation of nucleophosmin leukemic mutants.Semantic proximity Read ↗

NPM1-mutated acute myeloid leukemia: New pathogenetic and therapeutic insights and open questions.Semantic proximity Read ↗

Structural consequences of nucleophosmin mutations in acute myeloid leukemia.Semantic proximity Read ↗

NPM1-mutated acute myeloid leukemia: from bench to bedside.Semantic proximity Read ↗

Identification of a novel NPM1 mutation in acute myeloid leukemiaSemantic proximity Read ↗

Functions of the native NPM1 protein and its leukemic mutant.Semantic proximity Read ↗

Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications.Semantic proximity Read ↗

Nucleophosmin mutations in acute myeloid leukemia: a tale of protein unfolding and mislocalization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.